The purpose of this document is to ensure that biological materials are shipped in compliance with the US Department of Transportation (DOT) 49 CFR Part 173, International Civil Aviation Organization (ICAO) regulations as defined by the International Air Transport Association (IATA). Non-compliance with the shipping regulations may result in fines, imprisonment, and/or loss of shipping privileges. This SOP provides guidance in determining whether your biological shipment is regulated by DOT or ICAO. While packaging and documentation instructions are provided in this SOP, personnel must be trained and certified to ship regulated biological materials. MIT EHS Office will train and certify individuals to ship biological materials on dry ice excluding Category A Infectious Substances such as HIV or Hepatitis C virus.Only the EHS Biosafety Program can ship Category A Infectious Substances. Alternatively, individuals may contact EHS for shipping assistance.